Article
Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration.
Science (New York, N.Y.) - 27 Apr 2001
Kramer S G, Kidd T, Simpson J H, Goodman C S
Abstract excerpt
Slit is secreted by cells at the midline of the central nervous system, where it binds to Roundabout (Robo) receptors and functions as a potent repellent. We found that migrating mesodermal cells in vivo respond to Slit as both an attractant and a repellent and that Robo receptors are required for both functions. Mesoderm cells expressing Robo receptors initially migrate away from Slit at the midline. A few hours...
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