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Article

To cross or not to cross: a genetic analysis of guidance at the midline.

Perspectives on developmental neurobiology - 1 Jan 1993

Tear G, Seeger M, Goodman C S

Abstract excerpt

Previous studies have led to the suggestion that the midline of the developing Drosophila central nervous system might serve a dual function during growth cone guidance, providing attractive signals for those growth cones that project across the midline, and at the same time repulsive signals for those growth cones that stay on only their own side. In an attempt to discover some of the genes encoding key...

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PMID: 8087543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

To cross or not to cross: a genetic analysis of guidance at the midline.PMID 8087543Read ↗

Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline.Semantic proximity Read ↗

The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance.Semantic proximity Read ↗

Axon guidance at the midline choice point.Semantic proximity Read ↗

Abelson tyrosine kinase is required to transduce midline repulsive cues.Semantic proximity Read ↗

Role of the midline glia and neurons in the formation of the axon commissures in the central nervous system of the Drosophila embryo.Semantic proximity Read ↗

Axon guidance at the midline: from mutants to mechanisms.Semantic proximity Read ↗

Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline.Semantic proximity Read ↗

Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance.Semantic proximity Read ↗

Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline.Semantic proximity Read ↗

Crossing the midline: roles and regulation of Robo receptors.Semantic proximity Read ↗

Calmodulin and son of sevenless dependent signaling pathways regulate midline crossing of axons in the Drosophila CNS.Semantic proximity Read ↗

Roundabout signalling, cell contact and trophic support confine longitudinal glia and axons in the Drosophila CNS.Semantic proximity Read ↗

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