The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system.

doi:10.1016/0092-8674(95)90093-4

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Article

The stabilization of repetitive tracts of DNA by variant repeats requires a functional DNA mismatch repair system.

Cell - 17 Nov 1995

Heale S M, Petes T D

Abstract excerpt

Simple repetitive tracts of DNA are unstable in all organisms thus far examined. In the yeast S. cerevisiae, we show that a 51 bp poly(GT) tract alters length at a rate of about 10(-5) per cell division. Insertion of a single variant repeat (either AT or CT) into the middle of the poly(GT) tract...

Topics

Base Sequence
DNA Repair
DNA-Directed DNA Polymerase
Genotype
Molecular Sequence Data
Repetitive Sequences, Nucleic Acid
Yeasts

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