Article
Frameshift mutagenesis: the roles of primer-template misalignment and the nonhomologous end-joining pathway in Saccharomyces cerevisiae.
Genetics - 1 Feb 2012
Lehner Kevin, Mudrak Sarah V, Minesinger Brenda K, Jinks-Robertson Sue
Abstract excerpt
Small insertions or deletions that alter the reading frame of a gene typically occur in simple repeats such as mononucleotide runs and are thought to reflect spontaneous primer-template misalignment during DNA replication. The resulting extrahelical repeat is efficiently recognized by the mismatch repair machinery, which specifically replaces the newly replicated strand to restore the original sequence....
Topics
- Alleles
- Base Pair Mismatch
- Base Sequence
- DNA End-Joining Repair
- DNA Mismatch Repair
- DNA Replication
- Frameshift Mutation
- Gene Duplication
- Molecular Sequence Data
- Mutagenesis
- Recombination, Genetic
- Saccharomyces cerevisiae