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Article

Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Galphaq protein-induced cardiomyopathy.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2010

Timofeyev Valeriy, Porter Cliff A, Tuteja Dipika, Qiu Hong, Li Ning, Tang Tong, Singapuri Anil, Han Pyung-Lim, Lopez Javier E, Hammond H Kirk, Chiamvimonvat Nipavan

Abstract excerpt

Adenylyl cyclase (AC) is the principal effector molecule in the β-adrenergic receptor pathway. AC(V) and AC(VI) are the two predominant isoforms in mammalian cardiac myocytes. The disparate roles among AC isoforms in cardiac hypertrophy and progression to heart failure have been under intense investigation. Specifically, the salutary effects resulting from the disruption of AC(V) have been established in multiple...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20709863
DOI: 10.1152/ajpheart.01208.2009
PMCID: PMC2993201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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