Article
Validation for the function of protein C in mouse models.
PeerJ - 1 Jan 2024
Liu Ya, Cai Maoping, Chen Yan, Wu Guocai, Li Songyu, Chen Zhanghui
Abstract excerpt
Objectives: Protein C (PC) is an anticoagulant that is encoded by the PROC gene. Validation for the function of PC was carried out in mouse models. Methods: In this study, autosomal recessive PC deficiency (PCD) was selected as the target, and the specific mutation site was chromosome 2 2q13-q14, PROC c.1198G>A (p.Gly400Ser) which targets G399S (GGT to AGC) in mouse models. To investigate the role of hereditary...
Topics
- Animals
- Protein C
- Mice
- Disease Models, Animal
- Protein C Deficiency
- Mutation
- Male
- Female
- Blood Coagulation
- Heterozygote
- Gene Editing
- CRISPR-Cas Systems
- Partial Thromboplastin Time