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Article

Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells.

Genes & development - 15 Jan 2001

Kannouche P, Broughton B C, Volker M, Hanaoka F, Mullenders L H, Lehmann A R

Abstract excerpt

DNA polymerase eta carries out translesion synthesis past UV photoproducts and is deficient in xeroderma pigmentosum (XP) variants. We report that poleta is mostly localized uniformly in the nucleus but is associated with replication foci during S phase. Following treatment of cells with UV irradiation or carcinogens, it accumulates at replication foci stalled at DNA damage. The C-terminal third of poleta is not...

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Identifiers

PMID: 11157773
DOI: 10.1101/gad.187501
PMCID: PMC312610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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