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Article

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta.

Nature - 17 Jun 1999

Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F

Abstract excerpt

Xeroderma pigmentosum variant (XP-V) is an inherited disorder which is associated with increased incidence of sunlight-induced skin cancers. Unlike other xeroderma pigmentosum cells (belonging to groups XP-A to XP-G), XP-V cells carry out normal nucleotide-excision repair processes but are defect...

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PMID: 10385124
DOI: 10.1038/21447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10385124-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta.PMID 10385124Read ↗

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Role of DNA polymerase eta in the UV mutation spectrum in human cells.Semantic proximity Read ↗

Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations.Semantic proximity Read ↗

Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients.Semantic proximity Read ↗

Molecular genetics of Xeroderma pigmentosum variant.Semantic proximity Read ↗

Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene.Semantic proximity Read ↗

Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells.Semantic proximity Read ↗

Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cellsSemantic proximity Read ↗

The RAD30 cancer susceptibility gene.Semantic proximity Read ↗

DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.Semantic proximity Read ↗

ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cellsSemantic proximity Read ↗

DNA damage responses protect xeroderma pigmentosum variant from UVC-induced clastogenesis.Semantic proximity Read ↗

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