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Article

Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002

Broughton Bernard C, Cordonnier Agnes, Kleijer Wim J, Jaspers Nicolaas G J, Fawcett Heather, Raams Anja, Garritsen Victor H, Stary Anne, Avril Marie-Françoise, Boudsocq Francois, Masutani Chikahide, Hanaoka Fumio, Fuchs Robert P, Sarasin Alain, Lehmann Alan R

Abstract excerpt

Xeroderma pigmentosum variant (XP-V) cells are deficient in their ability to synthesize intact daughter DNA strands after UV irradiation. This deficiency results from mutations in the gene encoding DNA polymerase eta, which is required for effecting translesion synthesis (TLS) past UV photoproducts. We have developed a simple cellular procedure to identify XP-V cell strains, and have subsequently analyzed the...

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Identifiers

PMID: 11773631
DOI: 10.1073/pnas.022473899
PMCID: PMC117388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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