Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin.

International journal of cancer - 1 Nov 2006

Glick Eitan, White Lisa M, Elliott Nathan A, Berg Daniel, Kiviat Nancy B, Loeb Lawrence A

Abstract excerpt

The major etiological agent in skin cancer is exposure to UV-irradiation and the concomitant DNA damage. UV-induced DNA lesions, such as thymine dimers, block DNA synthesis by the major DNA polymerases and inhibit the progression of DNA replication. Bypass of thymine dimers and related lesions is dependent on the translesion polymerase DNA polymerase eta (Poleta). In the inherited disorder, xeroderma pigmentosum...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Base Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to DNA-Directed DNA Polymerase

Share to DNA Primers

Share to Polymerase Chain Reaction

Share to Skin Neoplasms

Share to White People

Source

Identifiers

PMID: 16823845
DOI: 10.1002/ijc.22099

Genes

POLH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin.PMID 16823845Read ↗

The human POLH gene is not mutated, and is expressed in a cohort of patients with basal or squamous cell carcinoma of the skin.Semantic proximity Read ↗

Xeroderma pigmentosum-variant patients from America, Europe, and Asia.Semantic proximity Read ↗

Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts.Semantic proximity Read ↗

Mutational signatures and increased retrotransposon insertions in Xeroderma Pigmentosum variant skin tumorsSemantic proximity Read ↗

The role of DNA polymerase eta in UV mutational spectra.Semantic proximity Read ↗

Mutational signatures and increased retrotransposon insertions in xeroderma pigmentosum variant skin tumors.Semantic proximity Read ↗

DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.Semantic proximity Read ↗

Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells.Semantic proximity Read ↗

Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.Semantic proximity Read ↗

Variants of the xeroderma pigmentosum variant gene (POLH) are associated with melanoma risk.Semantic proximity Read ↗

Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells.Semantic proximity Read ↗

Role of DNA polymerase eta in the UV mutation spectrum in human cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.