Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells

1 Feb 2010

Abstract excerpt

DNA polymerase eta (poleta) performs translesion synthesis past ultraviolet (UV) photoproducts and is deficient in cancer-prone xeroderma pigmentosum variant (XP-V) syndrome. The slight sensitivity of XP-V cells to UV is dramatically enhanced by low concentrations of caffeine. So far, the biological explanation for this feature remains elusive. Using DNA combing, we showed that translesion synthesis defect leads...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20123862
DOI: 10.1093/hmg/ddq046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cellsPMID 20123862Read ↗

DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.Semantic proximity Read ↗

Enhanced S phase delay and inhibition of replication of an undamaged shuttle vector in UVC-irradiated xeroderma pigmentosum variant.Semantic proximity Read ↗

DNA damage responses protect xeroderma pigmentosum variant from UVC-induced clastogenesis.Semantic proximity Read ↗

Regulation of Cellular and SV40 Virus Origins of Replication by Chk1-dependent Intrinsic and UVC Radiation-induced CheckpointsSemantic proximity Read ↗

Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cellsSemantic proximity Read ↗

A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response in human cellsSemantic proximity Read ↗

DNA end resection is needed for the repair of complex lesions in G1-phase human cellsSemantic proximity Read ↗

Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.Semantic proximity Read ↗

Rad51 and Mitotic Function of Mus81 are Essential for Recovery from Low-Dose of Camptothecin in the Absence of the Wrn ExonucleaseSemantic proximity Read ↗

The Dispersal of Replication Proteins after Etoposide Treatment Requires the Cooperation of Nbs1 with the Ataxia Telangiectasia Rad3-Related/Chk1 PathwaySemantic proximity Read ↗

PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cellsSemantic proximity Read ↗

An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.