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Article

Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.

DNA repair - 1 May 2009

Akagi Jun-Ichi, Masutani Chikahide, Kataoka Yuki, Kan Takashi, Ohashi Eiji, Mori Toshio, Ohmori Haruo, Hanaoka Fumio

Abstract excerpt

Defects in the gene encoding human Poleta result in xeroderma pigmentosum variant (XP-V), an inherited cancer-prone syndrome. Poleta catalyzes efficient and accurate translesion DNA synthesis (TLS) past UV-induced lesions. In addition to Poleta, human cells have multiple TLS polymerases such as Poliota, Polkappa, Polzeta and REV1. REV1 physically interacts with other TLS polymerases, but the physiological...

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Identifiers

PMID: 19157994
DOI: 10.1016/j.dnarep.2008.12.006

Genes

REV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.PMID 19157994Read ↗

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