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Article

EGFR and IGF-1R in regulation of prostate cancer cell phenotype and polarity: opposing functions and modulation by T-cadherin.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2015

Maslova Kseniya, Kyriakakis Emmanouil, Pfaff Dennis, Frachet Audrey, Frismantiene Agne, Bubendorf Lukas, Ruiz Christian, Vlajnic Tatjana, Erne Paul, Resink Thérèse J, Philippova Maria

Abstract excerpt

T-cadherin is an atypical glycosylphosphatidylinsoitol-anchored member of the cadherin superfamily of adhesion molecules. We found that T-cadherin overexpression in malignant (DU145) and benign (BPH-1) prostatic epithelial cell lines or silencing in the BPH-1 cell line, respectively, promoted or inhibited migration and spheroid invasion in collagen I gel and Matrigel. T-cadherin-dependent effects were associated...

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PMID: 25381040
DOI: 10.1096/fj.14-249367

Genes

EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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