Article
Two regions of cadherin cytoplasmic domains are involved in suppressing motility of a mammary carcinoma cell line.
The Journal of biological chemistry - 26 Dec 2003
Fedor-Chaiken Mary, Meigs Thomas E, Kaplan Daniel D, Brackenbury Robert
Abstract excerpt
E-cadherin has been termed an "invasion suppressor," yet the mechanism of this suppression is not known. In contrast, several reports indicate N-cadherin does not suppress but, rather, promotes cell motility and invasion. Here, by characterizing a series of chimeric cadherins we defined a previously uncharacterized region consisting of the transmembrane domain and an adjacent portion of the cytoplasmic segment...
Topics
- Amino Acid Sequence
- Animals
- Breast Neoplasms
- Cadherins
- Cell Line, Tumor
- Cell Movement
- Cytoplasm
- Cytoskeletal Proteins
- Gene Deletion
- Genetic Vectors
- Humans
- Immunoblotting
- Mice
- Molecular Sequence Data