Chromosome 5 suppresses tumorigenicity of PC3 prostate cancer cells: correlation with re-expression of alpha-catenin and restoration of E-cadherin function.

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Article

Chromosome 5 suppresses tumorigenicity of PC3 prostate cancer cells: correlation with re-expression of alpha-catenin and restoration of E-cadherin function.

Cancer research - 1 Nov 1995

Ewing C M, Ru N, Morton R A, Robinson J C, Wheelock M J, Johnson K R, Barrett J C, Isaacs W B

Abstract excerpt

Considerable evidence now exists to support an important role for the E-cadherin-mediated cell-cell adhesion pathway as a suppressor of the invasive phenotype in adenocarcinoma cells. Previous studies have found that this pathway is frequently aberrant in prostate cancers, particularly those that...

Topics

Animals
Cadherins
Cell Adhesion
Cell Communication
Cell Division
Chromosomes, Human, Pair 5
Cytoskeletal Proteins
DNA
Gene Expression
Humans
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Nude

Phenotype

Prostatic Neoplasms

Transfection

Tumor Cells, Cultured

alpha Catenin

Source

Open in PubMed

Identifiers

PMID: 7585512

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7585512-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Chromosome 5 suppresses tumorigenicity of PC3 prostate cancer cells: correlation with re-expression of alpha-catenin and restoration of E-cadherin function.PMID 7585512Read ↗

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Suppression of prostate cancer invasive potential and matrix metalloproteinase activity by E-cadherin transfection.Semantic proximity Read ↗

Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma.Semantic proximity Read ↗

The human Y chromosome suppresses the tumorigenicity of PC‐3, a human prostate cancer cell line, in athymic nude miceSemantic proximity Read ↗

Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39.Semantic proximity Read ↗

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