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Article

Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase.

Cellular signalling - 1 Dec 2000

Li Y, Jiang B, Ensign W Y, Vogt P K, Han J

Abstract excerpt

Activation of phosphatidylinositol 3-kinase (PI 3-kinase) or of Akt induces myoblast differentiation. Activation of p38 MAP kinase also triggers myogenic differentiation. The current paper shows that PI 3-kinase and p38 MAP kinase signalling are activated by two separate pathways during myogenic differentiation; both are required for muscle differentiation. p38-induced myogenic differentiation can be inhibited by...

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Identifiers

PMID: 11152961
DOI: 10.1016/s0898-6568(00)00120-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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