Raf-induced effects on the differentiation and apoptosis of skeletal myoblasts are determined by the level of Raf signaling: abrogation of apoptosis by Raf is downstream of caspase 3 activation.

Abstract excerpt

We examined the effect of a constitutively active Raf protein (Raf-CAAX) on the differentiation and the coincident apoptosis of skeletal myoblasts. We found that a low level of Raf signaling leads to accelerated differentiation when compared to parental myoblasts, while a higher level of Raf sign...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Calcium-Calmodulin-Dependent Protein Kinases
• Share to Caspase 3
• Share to Caspases