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Article

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

Science (New York, N.Y.) - 26 Nov 1999

Rommel C, Clarke B A, Zimmermann S, Nuñez L, Rossman R, Reid K, Moelling K, Yancopoulos G D, Glass D J

Abstract excerpt

Extracellular signals often result in simultaneous activation of both the Raf-MEK-ERK and PI3K-Akt pathways (where ERK is extracellular-regulated kinase, MEK is mitogen-activated protein kinase or ERK kinase, and PI3K is phosphatidylinositol 3-kinase). However, these two signaling pathways were shown to exert opposing effects on muscle cell hypertrophy. Furthermore, the PI3K-Akt pathway was shown to inhibit the...

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Identifiers

PMID: 10576741
DOI: 10.1126/science.286.5445.1738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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