Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells.

doi:10.1021/acssynbio.8b00163

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Article

Designing Motif-Engineered Receptors To Elucidate Signaling Molecules Important for Proliferation of Hematopoietic Stem Cells.

ACS synthetic biology - 20 Jul 2018

Ishizuka Shuta, Lai Chen-Yi, Otsu Makoto, Nakauchi Hiromitsu, Nagamune Teruyuki, Kawahara Masahiro

Abstract excerpt

The understanding of signaling events is critical for attaining long-term expansion of hematopoietic stem cells ex vivo. In this study, we aim to analyze the contribution of multiple signaling molecules in proliferation of hematopoietic stem cells. To this end, we design a bottom-up engineered receptor with multiple tyrosine motifs, which can recruit multiple signaling molecules of interest. This is followed by a...

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PMID: 29920201
DOI: 10.1021/acssynbio.8b00163

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STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.