Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations.

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Article

Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations.

Blood - 15 Apr 1996

Majumdar M K, Everett E T, Xiao X, Cooper R, Langley K, Kapur R, Vik T, Williams D A

Abstract excerpt

Mutations of c-kit, which encodes a transmembrane receptor tyrosine kinase, have been identified in mice by abnormal coat color, anemia, and germ cell defects. Mice heterozygous for mutations of c-kit have a white forehead blaze and a white ventral spot, leading these mutants to be termed dominan...

Topics

Alleles
Anemia
Animals
Base Sequence
Epistasis, Genetic
Female
Genes, Dominant
Humans
Infertility
Male
Mice
Mice, Transgenic
Molecular Sequence Data
Phenotype
Pigmentation Disorders
Proto-Oncogene Proteins c-kit
Recombinant Fusion Proteins
Stem Cell Factor

Source

Open in PubMed

Identifiers

PMID: 8605335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8605335-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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