Article
The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population.
Metabolism: clinical and experimental - 1 Mar 2008
Hamada Taku, Kotani Kazuhiko, Fujiwara Shinji, Sano Yoshiko, Domichi Masayuki, Tsuzaki Kokoro, Sakane Naoki
Abstract excerpt
Uncoupling protein 3 (UCP3) is considered to be associated with obesity, given its function in the regulation of energy and lipid metabolism. An increased body mass index (BMI) and a decreased level of high-density lipoprotein cholesterol (HDL-C) are risk factors for cardiovascular disease. The purpose of this study was to investigate whether the UCP3 promoter -55 C/T single nucleotide polymorphism (UCP3 -55 C/T...
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