Article
The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.
Genes & development - 15 Feb 1994
Luetteke N C, Phillips H K, Qiu T H, Copeland N G, Earp H S, Jenkins N A, Lee D C
Abstract excerpt
Mice harboring the waved-1 (wa-1) and waved-2 (wa-2) mutations exhibit skin and eye abnormalities that are strikingly similar to those of TGF-alpha-deficient mice, and wa-1 and TGF-alpha were recently shown to be allelic. Because the wa-2 mutation was mapped previously to the vicinity of the EGF/TGF-alpha receptor (EGFR) gene on mouse chromosome 11, we hypothesized that the wa-2 phenotype might result from a...
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