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Article

Epidermal growth factor receptor inhibits colitis-associated cancer in mice.

The Journal of clinical investigation - 1 Aug 2012

Dubé Philip E, Yan Fang, Punit Shivesh, Girish Nandini, McElroy Steven J, Washington M Kay, Polk D Brent

Abstract excerpt

Inflammatory bowel disease (IBD) is a chronic illness caused by complex interactions between genetic and environmental factors that propagate inflammation and damage to the gastrointestinal epithelium. This state of chronic inflammation increases the risk for development of colitis-associated cancer in IBD patients. Thus, the development of targeted therapeutics that can disrupt the cycle of inflammation and...

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Identifiers

PMID: 22772467
DOI: 10.1172/JCI62888
PMCID: PMC3408743

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