Article
Development of colonic adenocarcinomas in a mouse model of ulcerative colitis.
Inflammatory bowel diseases - 1 Aug 1998
Shah S A, Simpson S J, Brown L F, Comiskey M, de Jong Y P, Allen D, Terhorst C
Abstract excerpt
Mice deficient in both interleukin-2 and beta 2-microglobulin expression (Beta 2mullnull x IL-2null mice) develop an inflammatory disease of the colon resembling ulcerative colitis. To examine long-term complications of disease in these mice, a group of 34 Beta 2mnull x IL-2null mice was monitored for 6-12 months. Development of clinical disease was assessed by wasting, general appearance, and diarrhea. Further...
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