Article

Retinoic Acid-Induced 2 Contributes to Proficient Homologous Recombination and Maintains Genomic Stability in Breast Cancer

2024-02-05

Abstract excerpt

<title>Abstract</title> <p>Background Genome instability is a fundamental feature and hallmark of cancer associated with aggressiveness, drug resistance and poor prognosis. RAI2 was initially identified as a novel metastasis suppressor protein specifically associated with the presence of disseminated tumour cells in the bone marrow of breast cancer patients, but its molecular function is largely unknown. Methods...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7253656b-7b40-5a09-a1c0-53c038b2fe5d
DOI: 10.21203/rs.3.rs-3908810/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Retinoic Acid-Induced 2 Contributes to Proficient Homologous Recombination and Maintains Genomic Stability in Breast CancerDOI 10.21203/rs.3.rs-3908810/v1Read

The mitotic checkpoint regulator RAE1 induces aggressive breast cancer cell phenotypes by mediating epithelial-mesenchymal transition.Semantic proximity Read

<i>BRCA2</i> abrogation triggers innate immune responses potentiated by treatment with PARP inhibitorsSemantic proximity Read

Tumour suppressor mechanisms in the control of chromosome stability: insights from BRCA2.Semantic proximity Read

Jab1 regulates HRR mRNA stability to modulate PARP inhibitor sensitivity in triple-negative breast cancerSemantic proximity Read

Mechanisms underlying genome maintenance and tumour suppression by BRCA2Semantic proximity Read

A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic StabilitySemantic proximity Read

Chromosome stability, DNA recombination and the BRCA2 tumour suppressor.Semantic proximity Read

Low E2F2 activity is associated with high genomic instability and PARPi resistanceSemantic proximity Read

Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional RegulationSemantic proximity Read

Differential Regulation of Retinoic Acid Metabolism in Fanconi AnemiaSemantic proximity Read

The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers.Semantic proximity Read

Cell cycle and apoptosis regulator 2 at the interface between DNA damage response and cell physiology.Semantic proximity Read