Article
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents.
Nature - 1 Jan 2000
Hanaoka K, Qian F, Boletta A, Bhunia A K, Piontek K, Tsiokas L, Sukhatme V P, Guggino W B, Germino G G
Abstract excerpt
The human kidney is composed of roughly 1.2-million renal tubules that must maintain their tubular structure to function properly. In autosomal dominant polycystic kidney disease (ADPKD) cysts develop from renal tubules and enlarge independently, in a process that ultimately causes renal failure in 50% of affected individuals. Mutations in either PKD1 or PKD2 are associated with ADPKD but the function of these...
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