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Article

Molecular pathogenesis of ADPKD: the polycystin complex gets complex.

Kidney international - 1 Apr 2005

Ong Albert C M, Harris Peter C

Abstract excerpt

Autosomal-dominant polycystic kidney disease (ADPKD) is one of the most common human monogenic diseases with an incidence of 1:400 to 1:1000. It is characterized by the progressive development and enlargement of focal cysts in both kidneys, typically resulting in end-stage renal disease (ESRD) by the fifth decade. The cystogenic process is highly complex with a cellular phenotype consistent with...

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Source

Identifiers

PMID: 15780076
DOI: 10.1111/j.1523-1755.2005.00201.x

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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