Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.

The EMBO journal - 7 Apr 2010

Giamarchi Aurélie, Feng Shuang, Rodat-Despoix Lise, Xu Yaoxian, Bubenshchikova Ekaterina, Newby Linda J, Hao Jizhe, Gaudioso Christelle, Crest Marcel, Lupas Andrei N, Honoré Eric, Williamson Michael P, Obara Tomoko, Ong Albert C M, Delmas Patrick

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in two genes, PKD1 and PKD2, which encode polycystin-1 (PC1) and polycystin-2 (PC2), respectively. Earlier work has shown that PC1 and PC2 assemble into a polycystin complex implicated in kidney morphogenesis. PC2 also as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Dimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Kidney

Share to Polycystic Kidney, Autosomal Dominant

Share to TRPP Cation Channels

Share to Two-Hybrid System Techniques

Share to Zebrafish

Source

Open in PubMed Open full text

Identifiers

PMID: 20168298
DOI: 10.1038/emboj.2010.18
PMCID: PMC2857461

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20168298-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.PMID 20168298Read ↗

Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2.Semantic proximity Read ↗

Structural studies of the C‐terminal tail of polycystin‐2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2Semantic proximity Read ↗

Polycystin-1 maturation requires polycystin-2 in a dose-dependent mannerSemantic proximity Read ↗

Autosomal dominant polycystic kidney disease: clues to pathogenesis.Semantic proximity Read ↗

The TRPP subfamily and polycystin-1 proteins.Semantic proximity Read ↗

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents.Semantic proximity Read ↗

Genomic Organization and Functional Analysis of Murine PKD2L1Semantic proximity Read ↗

Polycystin-2 (PC2): structural insights and its role in disease pathogenesis.Semantic proximity Read ↗

A polycystin-centric view of cyst formation and disease: the polycystins revisited.Semantic proximity Read ↗

Functionally conserved Pkd2, mutated in autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates cytoplasmic calcium homeostasis in fission yeastSemantic proximity Read ↗

The polycystins: a novel class of membrane-associated proteins involved in renal cystic disease.Semantic proximity Read ↗

Structural and molecular basis of the assembly of the TRPP2/PKD1 complexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.