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Article

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.

The EMBO journal - 7 Apr 2010

Giamarchi Aurélie, Feng Shuang, Rodat-Despoix Lise, Xu Yaoxian, Bubenshchikova Ekaterina, Newby Linda J, Hao Jizhe, Gaudioso Christelle, Crest Marcel, Lupas Andrei N, Honoré Eric, Williamson Michael P, Obara Tomoko, Ong Albert C M, Delmas Patrick

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in two genes, PKD1 and PKD2, which encode polycystin-1 (PC1) and polycystin-2 (PC2), respectively. Earlier work has shown that PC1 and PC2 assemble into a polycystin complex implicated in kidney morphogenesis. PC2 also assembles into homomers of uncertain functional significance. However, little is known about the molecular mechanisms...

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Source

Open in PubMed Open full text

Identifiers

PMID: 20168298
DOI: 10.1038/emboj.2010.18
PMCID: PMC2857461

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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