Article
New insights into polycystic kidney disease and its treatment.
Current opinion in nephrology and hypertension - 1 Mar 1998
Torres V E
Abstract excerpt
Major advances in the understanding of the genetics and pathogenesis of autosomal dominant polycystic kidney disease have occurred within the past year. The proteins encoded by the PKD1 and PKD2 genes, polycystin 1 and polycystin 2, are membrane proteins, capable of interacting physically in vitro, and are likely components of a complex signalling pathway. The majority of PKD1 and PKD2 mutations so far identified...
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