Article
Substitution rates in Drosophila nuclear genes: implications for translational selection.
Genetics - 1 Jan 2001
Dunn K A, Bielawski J P, Yang Z
Abstract excerpt
The relationships between synonymous and nonsynonymous substitution rates and between synonymous rate and codon usage bias are important to our understanding of the roles of mutation and selection in the evolution of Drosophila genes. Previous studies used approximate estimation methods that ignore codon bias. In this study we reexamine those relationships using maximum-likelihood methods to estimate substitution...
Topics
- Animals
- Cell Nucleus
- Codon
- Computer Simulation
- Drosophila
- Drosophila melanogaster
- Genes, Insect
- Likelihood Functions
- Models, Genetic
- Mutation
- Protein Biosynthesis
- Selection, Genetic