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Article

The correlation between synonymous and nonsynonymous substitutions in Drosophila: mutation, selection or relaxed constraints?

Genetics - 1 Oct 1998

Comeron J M, Kreitman M

Abstract excerpt

Codon usage bias, the preferential use of particular codons within each codon family, is characteristic of synonymous base composition in many species, including Drosophila, yeast, and many bacteria. Preferential usage of particular codons in these species is maintained by natural selection acting largely at the level of translation. In Drosophila, as in bacteria, the rate of synonymous substitution per site is...

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PMID: 9755207
DOI: 10.1093/genetics/150.2.767
PMCID: PMC1460343

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