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Article

Synonymous and nonsynonymous rate variation in nuclear genes of mammals.

Journal of molecular evolution - 1 Apr 1998

Yang Z, Nielsen R

Abstract excerpt

A maximum likelihood approach was used to estimate the synonymous and nonsynonymous substitution rates in 48 nuclear genes from primates, artiodactyls, and rodents. A codon-substitution model was assumed, which accounts for the genetic code structure, transition/transversion bias, and base frequency biases at codon positions. Likelihood ratio tests were applied to test the constancy of nonsynonymous to synonymous...

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PMID: 9541535
DOI: 10.1007/pl00006320

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