Article
Genetic and phenotypic studies of the dark-like mutant mouse.
Genesis (New York, N.Y. : 2000) - 1 Oct 2008
Cota Christina D, Liu Roy R, Sumberac Theresa M, Jung SeungWoo, Vencato Daniela, Millet Yoann H, Gunn Teresa M
Abstract excerpt
The dark-like (dal) mutant mouse has a pleiotropic phenotype that includes dark dorsal hairs and reproductive degeneration. Their pigmentation phenotype is similar to Attractin (Atrn) mutants, which also develop vacuoles throughout the brain. In further characterizing the testicular degeneration of dal mutant males, we found that they had reduced serum testosterone and developed vacuoles in their testes. Genetic...
Topics
- Agouti Signaling Protein
- Animals
- Calcium-Binding Proteins
- EGF Family of Proteins
- Female
- Hair
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred CBA
- Molecular Sequence Data
- Mutation
- Phenotype
- Pigmentation
- Proteins
- Signal Transduction