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Article

Accessory proteins for melanocortin signaling: attractin and mahogunin.

Annals of the New York Academy of Sciences - 1 Jun 2003

He Lin, Eldridge Adam G, Jackson Peter K, Gunn Teresa M, Barsh Gregory S

Abstract excerpt

Switching from eumelanin to pheomelanin synthesis during hair growth is accomplished by transient synthesis of Agouti protein, an inverse agonist for the melanocortin-1 receptor (Mc1r). The coat color mutations mahogany and mahoganoid prevent hair follicle melanocytes from responding to Agouti protein. The gene mutated in mahogany, which is also known as Attractin (Atrn), encodes a type I transmembrane protein...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12851328
DOI: 10.1111/j.1749-6632.2003.tb03192.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Accessory proteins for melanocortin signaling: attractin and mahogunin.PMID 12851328Read ↗

The mouse mahogany locus encodes a transmembrane form of human attractin.Semantic proximity Read ↗

Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.Semantic proximity Read ↗

Mahogany/attractin: en route from phenotype to function.Semantic proximity Read ↗

A biochemical function for attractin in agouti-induced pigmentation and obesity.Semantic proximity Read ↗

Genetic analysis of attractin homologs.Semantic proximity Read ↗

Spongiform degeneration in mahoganoid mutant mice.Semantic proximity Read ↗

Attractin: cautionary tales for therapeutic intervention in molecules with pleiotropic functionality.Semantic proximity Read ↗

Attractin/mahogany/zitter plays a critical role in myelination of the central nervous system.Semantic proximity Read ↗

Genetic studies of the mouse mutations mahogany and mahoganoid.Semantic proximity Read ↗

Molecular and phenotypic analysis of Attractin mutant mice.Semantic proximity Read ↗

The mahogany mouse mutation: further links between pigmentation, obesity and the immune system.Semantic proximity Read ↗

The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.Semantic proximity Read ↗

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