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Article

Evidence forRAD51L1/HMGIC fusion in the pathogenesis of uterine leiomyoma

1 Feb 2001

Abstract excerpt

Chromosome rearrangements involving 12q15 are frequently observed in a variety of human mesenchymal tumors. The high mobility group protein gene HMGIC has been identified as the target involved in these rearrangements. Uterine leiomyomas frequently use chromosome band 14q24 as a translocation partner to HMGIC. Recent studies within the chromosome 14 breakpoint region in cell lines carrying t(12;14)(q15;q23-24)...

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Identifiers

PMID: 11135437
DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1078>3.0.co;2-8

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence forRAD51L1/HMGIC fusion in the pathogenesis of uterine leiomyomaPMID 11135437Read ↗

Fusion of a Sequence from HEI10 (14q11) to the HMGIC Gene at 12ql5 in a Uterine LeiomyomaSemantic proximity Read ↗

Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas.Semantic proximity Read ↗

Translocation breakpoints upstream of theHMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomasSemantic proximity Read ↗

Gene fusion involving HMGIC is a frequent aberration in uterine leiomyomas.Semantic proximity Read ↗

Novel gene fusion ofCOX6C at 8q22-23 toHMGIC at 12q15 in a uterine leiomyomaSemantic proximity Read ↗

HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes.Semantic proximity Read ↗

HMGI(Y) and HMGI-C DysregulationSemantic proximity Read ↗

Chromosomal Translocations in Benign Tumors:<i>The HMGI Proteins</i>Semantic proximity Read ↗

HMGIC expression in human adult and fetal tissues and in uterine leiomyomataSemantic proximity Read ↗

Diagnosing and preventing inheirted diseaseSemantic proximity Read ↗

The t(3;12)(q27;q14-q15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype.Semantic proximity Read ↗

HMGIC alterations in smooth muscle tumors of soft tissues and other sites.Semantic proximity Read ↗

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