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Article

Gene fusion involving HMGIC is a frequent aberration in uterine leiomyomas.

Journal of human genetics - 1 Jan 2001

Mine N, Kurose K, Nagai H, Doi D, Ota Y, Yoneyama K, Konishi H, Araki T, Emi M

Abstract excerpt

HMGIC, a high-mobility-group protein gene encoding an architectural transcription factor, was recently identified as the target of gene fusion in a variety of human benign mesenchymal tumors; some of these events were chromosomal translocations involving 12q13-15. HMGIC consists of three DNA-binding domains (encoded by exons 1-3), a spacer, and an acidic carboxyl-terminal regulatory domain (exons 4-5). To...

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Share to Alternative Splicing
Share to Chromosome Breakage
Share to Chromosomes, Human, Pair 12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11450849
DOI: 10.1007/s100380170059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Gene fusion involving HMGIC is a frequent aberration in uterine leiomyomas.PMID 11450849Read ↗

Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas.Semantic proximity Read ↗

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HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes.Semantic proximity Read ↗

HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumorsSemantic proximity Read ↗

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Fusion of a Sequence from HEI10 (14q11) to the HMGIC Gene at 12ql5 in a Uterine LeiomyomaSemantic proximity Read ↗

Chromosomal Translocations in Benign Tumors:<i>The HMGI Proteins</i>Semantic proximity Read ↗

HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomasSemantic proximity Read ↗

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