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Article

Novel gene fusion ofCOX6C at 8q22-23 toHMGIC at 12q15 in a uterine leiomyoma

1 Mar 2000

Abstract excerpt

Cytogenetic analyses have shown that aberrations involving 12q13-15 are frequent chromosomal changes in a variety of human benign mesenchymal tumors, e.g., pleomorphic adenomas of the parotid gland, pulmonary chondroid hamartomas, lipomas, and uterine leiomyomas. Recently, the high-mobility group protein gene HMGIC was identified as the target gene affected by the 12q13-15 aberrations. Using 3' rapid...

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Identifiers

PMID: 10679920
DOI: 10.1002/(sici)1098-2264(200003)27:3<303::aid-gcc11>3.0.co;2-3

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel gene fusion ofCOX6C at 8q22-23 toHMGIC at 12q15 in a uterine leiomyomaPMID 10679920Read ↗

Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas.Semantic proximity Read ↗

Translocation breakpoints upstream of theHMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomasSemantic proximity Read ↗

Gene fusion involving HMGIC is a frequent aberration in uterine leiomyomas.Semantic proximity Read ↗

Fusion of a Sequence from HEI10 (14q11) to the HMGIC Gene at 12ql5 in a Uterine LeiomyomaSemantic proximity Read ↗

The t(3;12)(q27;q14-q15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype.Semantic proximity Read ↗

Evidence forRAD51L1/HMGIC fusion in the pathogenesis of uterine leiomyomaSemantic proximity Read ↗

HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes.Semantic proximity Read ↗

HMGIC expression in human adult and fetal tissues and in uterine leiomyomataSemantic proximity Read ↗

HMGIC alterations in smooth muscle tumors of soft tissues and other sites.Semantic proximity Read ↗

Chromosomal Translocations in Benign Tumors:<i>The HMGI Proteins</i>Semantic proximity Read ↗

HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumorsSemantic proximity Read ↗

HMGI(Y) and HMGI-C DysregulationSemantic proximity Read ↗

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