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Article

HMGIC expression in human adult and fetal tissues and in uterine leiomyomata

1 Aug 1999

Abstract excerpt

The high-mobility-group (HMG) protein gene, HMGIC, is localized to chromosome 12, band q15, a region often rearranged in benign mesenchymal tumors, including uterine leiomyomata. Although some evidence suggests a role in regulation of cell proliferation, the precise function of HMGIC in the development or progression of these tumors remains unclear. We investigated HMGIC expression in 17 fetal tissues (adrenal,...

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Identifiers

PMID: 10398424
DOI: 10.1002/(sici)1098-2264(199908)25:4<316::aid-gcc2>3.0.co;2-0

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HMGIC expression in human adult and fetal tissues and in uterine leiomyomataPMID 10398424Read ↗

HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes.Semantic proximity Read ↗

HMGIC alterations in smooth muscle tumors of soft tissues and other sites.Semantic proximity Read ↗

Translocation breakpoints upstream of theHMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomasSemantic proximity Read ↗

Three aberrant splicing variants of the HMGIC gene transcribed in uterine leiomyomas.Semantic proximity Read ↗

HMGI(Y) and HMGI-C DysregulationSemantic proximity Read ↗

Gene fusion involving HMGIC is a frequent aberration in uterine leiomyomas.Semantic proximity Read ↗

HMG chromosomal proteins in development and disease.Semantic proximity Read ↗

Fusion of a Sequence from HEI10 (14q11) to the HMGIC Gene at 12ql5 in a Uterine LeiomyomaSemantic proximity Read ↗

Novel gene fusion ofCOX6C at 8q22-23 toHMGIC at 12q15 in a uterine leiomyomaSemantic proximity Read ↗

[Genetics of uterine leiomyomata].Semantic proximity Read ↗

HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumorsSemantic proximity Read ↗

Expression ofHMGI-C, a member of the high mobility group protein family, in a subset of breast cancers: Relationship to histologic gradeSemantic proximity Read ↗

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