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Diagnosing and preventing inheirted disease

1 Apr 1996

Abstract excerpt

The results of cytogenetic studies of uterine leiomyomas have revealed that approximately 50% of these tumours are characterized by clonal chromosomal alterations. These karyotypic deviations are dominated by rearrangements involving a particular part of chromosome 12, i.e. region 12q13-15. We recently showed that the multiple aberration region on chromosome 12q15 harbours recurrent breakpoints frequently found...

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PMID: 9238692
DOI: 10.1093/molehr/2.4.277

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Diagnosing and preventing inheirted diseasePMID 9238692Read ↗

HMGI(Y) and HMGI-C DysregulationSemantic proximity Read ↗

HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes.Semantic proximity Read ↗

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Overexpression of <i>HMGA2</i> in uterine leiomyomas points to its general role for the pathogenesis of the diseaseSemantic proximity Read ↗

HMGIC expression in human adult and fetal tissues and in uterine leiomyomataSemantic proximity Read ↗

Systematic molecular and clinical analysis of uterine leiomyomas from fertile-aged women undergoing myomectomy.Semantic proximity Read ↗

Fusion of a Sequence from HEI10 (14q11) to the HMGIC Gene at 12ql5 in a Uterine LeiomyomaSemantic proximity Read ↗

Translocation breakpoints upstream of theHMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomasSemantic proximity Read ↗

Novel gene fusion ofCOX6C at 8q22-23 toHMGIC at 12q15 in a uterine leiomyomaSemantic proximity Read ↗

Evidence forRAD51L1/HMGIC fusion in the pathogenesis of uterine leiomyomaSemantic proximity Read ↗

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