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Article

HMGIC alterations in smooth muscle tumors of soft tissues and other sites.

Cancer genetics and cytogenetics - 1 Oct 2002

Hisaoka Masanori, Sheng Wei Qi, Tanaka Atuko, Hashimoto Hiroshi

Abstract excerpt

The HMGIC gene, which codes a protein that acts as an architectural transcription factor, is frequently rearranged in a variety of benign or locally aggressive mesenchymal tumors. In tumors of smooth muscle differentiation, only uterine leiomyoma and lipoleiomyoma are known to be associated with...

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PMID: 12419585
DOI: 10.1016/s0165-4608(02)00568-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12419585-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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HMGIC alterations in smooth muscle tumors of soft tissues and other sites.PMID 12419585Read ↗

HMGI-C and HMGI(Y) immunoreactivity correlates with cytogenetic abnormalities in lipomas, pulmonary chondroid hamartomas, endometrial polyps, and uterine leiomyomas and is compatible with rearrangement of the HMGI-C and HMGI(Y) genes.Semantic proximity Read ↗

Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors.Semantic proximity Read ↗

HMGIC expression in human adult and fetal tissues and in uterine leiomyomataSemantic proximity Read ↗

Gene fusion involving HMGIC is a frequent aberration in uterine leiomyomas.Semantic proximity Read ↗

Translocation breakpoints upstream of theHMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomasSemantic proximity Read ↗

HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumorsSemantic proximity Read ↗

HMGI(Y) and HMGI-C DysregulationSemantic proximity Read ↗

Chromosomal translocation t(8;12) induces aberrant <i>HMGIC</i> expression in aggressive angiomyxoma of the vulvaSemantic proximity Read ↗

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Chromosomal Translocations in Benign Tumors:<i>The HMGI Proteins</i>Semantic proximity Read ↗

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