Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endoplasmic reticulum retention determinants in the transmembrane and linker domains of cytochrome P450 2C1.

The Journal of biological chemistry - 23 Jun 2000

Szczesna-Skorupa E, Kemper B

Abstract excerpt

The cytochrome P450 2C1 N-terminal signal anchor sequence mediates direct retention of the protein in the endoplasmic reticulum and consists of a hydrophobic transmembrane domain, residues 3-20, followed by a hydrophilic linker, residues 21-28. Fusions of the N-terminal 21 or 28 amino acids of P450 2C1 to green fluorescent protein resulted in endoplasmic reticulum localization of the chimera in transfected cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to COS Cells
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P450 Family 2

Share to Endoplasmic Reticulum

Share to Molecular Sequence Data

Share to Protein Sorting Signals

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 10781599
DOI: 10.1074/jbc.M002394200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Endoplasmic reticulum retention determinants in the transmembrane and linker domains of cytochrome P450 2C1.PMID 10781599Read ↗

Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1).Semantic proximity Read ↗

CLIPR-59 is a lipid raft-associated protein containing a cytoskeleton-associated protein glycine-rich domain (CAP-Gly) that perturbs microtubule dynamics.Semantic proximity Read ↗

Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.Semantic proximity Read ↗

The N-terminal hydrophobic domain of P450c21 is required for membrane insertion and enzyme stability.Semantic proximity Read ↗

Relative proximity and orientation of helices 4 and 8 of the GLUT1 glucose transporter.Semantic proximity Read ↗

Modifications in the N-terminus of an insect cytochrome P450 enhance production of catalytically active protein in baculovirus-Sf9 cell expression systems.Semantic proximity Read ↗

The amino-terminal structures that determine topological orientation of cytochrome P-450 in microsomal membrane.Semantic proximity Read ↗

Functional analysis of human mitochondrial receptor Tom20 for protein import into mitochondria.Semantic proximity Read ↗

Expression of truncated forms of liver microsomal P450 cytochromes 2B4 and 2E1 in Escherichia coli: influence of NH2-terminal region on localization in cytosol and membranes.Semantic proximity Read ↗

Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.