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Article

Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicing.

The Journal of biological chemistry - 2 Feb 2001

Sun Q A, Zappacosta F, Factor V M, Wirth P J, Hatfield D L, Gladyshev V N

Abstract excerpt

Animal thioredoxin reductases (TRs) are selenocysteine-containing flavoenzymes that utilize NADPH for reduction of thioredoxins and other protein and nonprotein substrates. Three types of mammalian TRs are known, with TR1 being a cytosolic enzyme, and TR3, a mitochondrial enzyme. Previously characterized TR1 and TR3 occurred as homodimers of 55-57-kDa subunits. We report here that TR1 isolated from mouse liver,...

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PMID: 11060283
DOI: 10.1074/jbc.M004750200

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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