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Article

Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice

1 Jan 2001

Abstract excerpt

We previously reported a novel transgenic model expressing human angiotensinogen from the kidney androgen-regulated protein promoter, and demonstrated sexually dimorphic expression. Herein, we investigated the hormonal regulation of this transgene. Testosterone increased transgene expression in female mice in a dose- and time-dependent manner and was not detectable 3-days after treatment was halted. High doses of...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 11133514
DOI: 10.1152/ajprenal.2001.280.1.f54

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