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Article

Transgenic rats expressing the human ET-2 gene: a model for the study of endothelin actions in vivo.

Journal of molecular medicine (Berlin, Germany) - 1 Jul 1999

Liefeldt L, Schönfelder G, Böcker W, Hocher B, Talsness C E, Rettig R, Paul M

Abstract excerpt

Previous studies have characterized the endothelin peptides (ET-1, ET-2, ET-3) as strong vasoconstrictors which are possibly involved in the pathogenesis of cardiovascular disease. Whereas ET-1 and ET-3 have been characterized using a number of approaches, little is known about the function of ET-2. The aim of this study was to define the role of ET-2 in physiology and pathophysiology using a transgenic approach....

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PMID: 10494802
DOI: 10.1007/s001099900026

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