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Article

Hedgehog signalling in cancer.

Cellular and molecular life sciences : CMLS - 1 Nov 2000

Toftgård R

Abstract excerpt

Hedgehog signalling is a key regulator of embryonic development controlling proliferation and/or cell fate determination. With identification of the Hedgehog receptor PTCH1 as a tumour suppressor gene that underlies the human nevoid basal cell carcinoma syndrome (NBCCS), the Hedgehog signalling pathway was firmly linked to cancer. It now appears that constitutive activation of Hedgehog signalling, by inactivating...

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Source

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Identifiers

PMID: 11130178
DOI: 10.1007/PL00000654
PMCID: PMC11147108

Genes

PTCH1
GLI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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