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Article

Hedgehog signalling in skin development and cancer

31 Jul 2006

Abstract excerpt

Basal cell carcinoma (BCC) is the most common human malignancy, affecting 750,000 Americans each year. The understanding of mutations that are known to activate hedgehog (Hh) signalling pathway genes, including PATCHED (PTCH), sonic hedgehog (Shh) and smoothened (Smo), has substantially expanded our current understanding of the genetic basis of BCC development. The Hh signalling pathway is one of the most...

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Identifiers

PMID: 16881963
DOI: 10.1111/j.1600-0625.2006.00473.x

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