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Article

Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.

Current molecular medicine - 1 Sept 2009

Katoh Y, Katoh M

Abstract excerpt

Hedgehog signaling is aberrantly activated in glioma, medulloblastoma, basal cell carcinoma, lung cancer, esophageal cancer, gastric cancer, pancreatic cancer, breast cancer, and other tumors. Hedgehog signals activate GLI family members via Smoothened. RTK signaling potentiates GLI activity through PI3K-AKT-mediated GSK3 inactivation or RAS-STIL1-mediated SUFU inactivation, while GPCR signaling to Gs represses...

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Source

Identifiers

PMID: 19860666
DOI: 10.2174/156652409789105570

Genes

GLI1
BCL2
CFLAR
FOXF1
FOXL1
JAG2
PTCH1
PTCH2
BMI1
BMP4
CCND1
CCND2
FOXC2
FOXM1
GLI2
GREM1
MYCN
PRDM1
PTHLH
SHH
SNAI1
SNAI2
SUFU
TWIST2
ZEB1
ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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