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Article

A-ZIP/F-1 mice lacking white fat: a model for understanding lipoatrophic diabetes.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Nov 2000

Reitman M L, Gavrilova O

Abstract excerpt

The A-ZIP/F-1 mouse is lacking virtually all white adipose tissue. Like humans with extensive deficiencies of adipose tissue, the A-ZIP/F-1 mice develop a severe form of insulin resistant diabetes. We have studied the physiology of the A-ZIP/F-1 mice. Their adaptation to fasting is notable for its rapidity and the use of torpor, a hibernation-like state, to minimize energy needs. Transplantation of adipose tissue...

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Source

Identifiers

PMID: 11126232
DOI: 10.1038/sj.ijo.0801493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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