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Article

Ablation of adipose-HO-1 expression increases white fat over beige fat through inhibition of mitochondrial fusion and of PGC1α in female mice.

Hormone molecular biology and clinical investigation - 1 Aug 2017

Singh Shailendra P, Grant Ilana, Meissner Aliza, Kappas Attallah, Abraham Nader G

Abstract excerpt

Background Hmox1 plays an important role in the regulation of mitochondrial bioenergetics and function by regulating cellular heme-derived CO and bilirubin. Previous studies have demonstrated that global disruption of HO-1 in humans and mice resulted in severe organ dysfunction. Methods We investigated the potential role of adipose-specific-HO-1 genetic ablation on adipose tissue function, mitochondrial quality...

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Share to 3T3-L1 Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adipose Tissue, White

Share to Heme Oxygenase-1

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Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

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Source

Identifiers

PMID: 28763300
DOI: 10.1515/hmbci-2017-0027

Genes

FAS
PRDM16
SIRT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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