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Article

Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy.

Diabetes - 1 Sept 2002

Colombo Carlo, Cutson Jaime J, Yamauchi Toshimasa, Vinson Charles, Kadowaki Takashi, Gavrilova Oksana, Reitman Marc L

Abstract excerpt

Severe adipose tissue deficiency (lipoatrophy) causes insulin-resistant diabetes, elevated serum triglyceride and fatty acid levels, and massive triglyceride deposition in the liver. In lipoatrophic A-ZIP/F-1 mice, transplantation of normal adipose tissue greatly improved these parameters, wherea...

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Identifiers

PMID: 12196465
DOI: 10.2337/diabetes.51.9.2727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-12196465-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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